Thinness Vs. Obesity Not Directly Linked To Eating Habits, Study Suggests

ScienceDaily (Jun. 4, 2008) — Whether you are fat or thin isn't directly determined by your eating habits, suggest researchers who report new findings made in worms in the June issue of Cell Metabolism. While both feeding and fat in worms depends on serotonin levels in the nervous system, they found evidence that the nerve messenger acts through independent channels to control whether you eat versus what to do with those calories once you've eaten them.

"It says that the nervous system is a key regulator coordinating all energy-related processes through distinct molecular pathways," said Kaveh Ashrafi of the University of California, San Francisco. "The nervous system makes a decision about its state leading to effects on behavior, reproduction, growth and metabolism. These outputs are related, but they are not consequences of each other. It's not that feeding isn't important, but the neural control of fat is distinct from feeding."

If the results in worms can be extrapolated to humans, as Ashrafi suspects at a fundamental level they can given serotonin's ancient evolutionary origins, then the finding may have clinical implications.

"From a clinical perspective, this may mean you could develop therapeutic strategies to manipulate fat metabolism independently of what you eat," he said. "Now, the focus is primarily on feeding behavior. As important as that is, it's only part of the story. If the logic of the system is conserved across species, a strategy that focuses solely on behavior can only go so far. It may be one reason diets fail."

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